Pharmacological profile of a specific neutrophil elastase inhibitor, Sivelestat sodium hydrate.
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چکیده
منابع مشابه
Sivelestat sodium hydrate reduces radiation-induced lung injury in mice by inhibiting neutrophil elastase.
The aim of this study was to investigate whether sivelestat, a neutrophil elastase (NE) inhibitor, mitigates radiation-induced lung injury in mice. C57BL/6J mice were administered a dose of 20 Gy to the bilateral whole lungs. Sivelestat was administered immediately before and 1 h after irradiation in group RE2, and immediately before and 1, 3 and 6 h after irradiation in group RE4. Group R rece...
متن کاملUsefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis
BACKGROUND Neutrophil elastase plays a crucial role in the development of acute lung injury (ALI) in patients with systemic inflammatory response syndrome (SIRS). The clinical efficacy of the neutrophil elastase inhibitor, sivelestat, for patients with ALI associated with SIRS has not been convincingly demonstrated. The aim of this study was to determine if there are clinical features of patien...
متن کاملSivelestat, a neutrophil elastase inhibitor, reduces mortality rate of critically ill patients.
Many studies have suggested that neutrophil elastase (NE) may contribute to multiple organ failure (MOF) and acute injury of lung endothelial cells. It is therefore conceivable that NE inhibitors may improve the outcome of MOF patients. A synthetic NE inhibitor, sivelestat, which was developed and released in Japan, inhibited inflammatory reactions in various animal models. We examined the medi...
متن کاملA pilot randomized study of the neutrophil elastase inhibitor, Sivelestat, in patients undergoing cardiac surgery.
The primary objective of this study was to determine the feasibility and safety of treatment with Sivelestat in humans to attenuate post-cardiopulmonary bypass lung injury. Twenty patients scheduled to undergo on-pump coronary artery bypass surgery were randomized to receive either 0.3 mg/kg/h intravenous Sivelestat sodium (Sivelestat group; n=10) or isotonic sodium chloride solution (placebo g...
متن کاملClinical utility of the neutrophil elastase inhibitor sivelestat for the treatment of acute respiratory distress syndrome
Acute respiratory distress syndrome is a serious condition that can arise following direct or indirect lung injury. It is heterogeneous and has a high mortality rate. Supportive care is the mainstay of treatment and there is no definitive pharmacological treatment as yet. Sivelestat is a neutrophil elastase inhibitor approved in Japan and the Republic of Korea for acute lung injury, including a...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2003
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.122.151